1LN6
STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)
Summary for 1LN6
| Entry DOI | 10.2210/pdb1ln6/pdb |
| Related | 1EDS 1EDV 1EDW 1FDF 1JFP |
| Descriptor | RHODOPSIN, RETINAL (2 entities in total) |
| Functional Keywords | g-protein coupled receptor, metarhodopsin ii, rhodopsin, membrane protein |
| Cellular location | Membrane; Multi-pass membrane protein: P02699 |
| Total number of polymer chains | 1 |
| Total formula weight | 39315.89 |
| Authors | Choi, G.,Landin, J.,Galan, J.F.,Birge, R.R.,Albert, A.D.,Yeagle, P.L. (deposition date: 2002-05-03, release date: 2002-07-10, Last modification date: 2024-10-16) |
| Primary citation | Choi, G.,Landin, J.,Galan, J.F.,Birge, R.R.,Albert, A.D.,Yeagle, P.L. Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin. Biochemistry, 41:7318-7324, 2002 Cited by PubMed Abstract: The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha. PubMed: 12044163DOI: 10.1021/bi025507w PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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