1LN6

STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)

1LN6 の概要

• エントリーDOI: 10.2210/pdb1ln6/pdb
• 関連するPDBエントリー: 1EDS 1EDV 1EDW 1FDF 1JFP
• 分子名称: RHODOPSIN, RETINAL (2 entities in total)
• 機能のキーワード: g-protein coupled receptor, metarhodopsin ii, rhodopsin, membrane protein
• 細胞内の位置: Membrane; Multi-pass membrane protein: P02699
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39315.89

構造登録者

Choi, G.,Landin, J.,Galan, J.F.,Birge, R.R.,Albert, A.D.,Yeagle, P.L. (登録日: 2002-05-03, 公開日: 2002-07-10, 最終更新日: 2024-10-16)

主引用文献

Choi, G.,Landin, J.,Galan, J.F.,Birge, R.R.,Albert, A.D.,Yeagle, P.L.
Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin.
Biochemistry, 41:7318-7324, 2002

PubMed Abstract: The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.

PubMed: 12044163
DOI: 10.1021/bi025507w

実験手法

SOLUTION NMR