1LK6

Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide

Summary for 1LK6

Entry DOI	10.2210/pdb1lk6/pdb
Related	1BR8 1JVQ
Descriptor	antithrombin-III, antithrombin P14-P9 peptide, exogenous tripeptide formyl-MLF, ... (7 entities in total)
Functional Keywords	loop-sheet polymer, beta-barrel, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P01008
Total number of polymer chains	4
Total formula weight	101061.90
Authors	Zhou, A.,Huntington, J.A.,Lomas, D.A.,Carrell, R.W.,Stein, P.E. (deposition date: 2002-04-24, release date: 2003-06-03, Last modification date: 2023-08-16)
Primary citation	Zhou, A.,Stein, P.E.,Huntington, J.A.,Carrell, R.W. Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol J.Biol.Chem., 278:15116-15122, 2003 Cited by PubMed: 12578831 DOI: 10.1074/jbc.M211663200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation