1LHF

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-HOMOLYS-OH

1LHF の概要

分子名称ALPHA-THROMBIN, HIRUDIN, AC-(D)PHE-PRO-BOROHOMOLYS-OH, ... (5 entities in total)
機能のキーワードblood coagulation, plasma, calcium-binding, glycoprotein, duplication, vitamin k, zymogen, gamma-carboxyglutamic acid, acute phase, liver, hydrolase, serine protease, kringle, disease mutation, complex (serine protease-inhibitor), complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor)
由来する生物種Hirudo medicinalis (medicinal leech)
詳細
細胞内の位置Secreted, extracellular space P00734 P00734
ポリマー鎖数3
分子量合計35791.62
構造登録者
Weber, P.C.,Lee, S.L.,Lewandowski, F.A.,Schadt, M.C.,Chang, C.H.,Kettner, C.A. (登録日: 1994-12-27, 公開日: 1996-11-08, 最終更新日: 2011-07-13)
主引用文献
Weber, P.C.,Lee, S.L.,Lewandowski, F.A.,Schadt, M.C.,Chang, C.W.,Kettner, C.A.
Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.
Biochemistry, 34:3750-3757, 1995
PubMed: 7893672 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi00011a033
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.4 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers321.8%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード