1LAU

URACIL-DNA GLYCOSYLASE

1LAU の概要

• エントリーDOI: 10.2210/pdb1lau/pdb
• 分子名称: DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-)) (3 entities in total)
• 機能のキーワード: hydrolase, glycosidase, dna, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: Human herpesvirus 1 (Herpes simplex virus type 1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28234.07

構造登録者

Pearl, L.H.,Savva, R. (登録日: 1996-01-03, 公開日: 1996-06-10, 最終更新日: 2024-02-14)

主引用文献

Savva, R.,McAuley-Hecht, K.,Brown, T.,Pearl, L.
The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373:487-493, 1995

PubMed Abstract: The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes simplex virus type-1 reveals a new fold, distantly related to dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and with uracil, define the DNA-binding site and allow a detailed understanding of the exquisitely specific recognition of uracil in DNA. The overall structure suggests binding models for elongated single- and double-stranded DNA substrates. Conserved residues close to the uracil-binding site suggest a catalytic mechanism for hydrolytic base excision.

PubMed: 7845459
DOI: 10.1038/373487a0

実験手法

X-RAY DIFFRACTION (1.8 Å)