1L8W

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

1L8W の概要

• エントリーDOI: 10.2210/pdb1l8w/pdb
• 分子名称: VlsE1 (2 entities in total)
• 機能のキーワード: variable surface protein, vmp-like sequence, immune system
• 由来する生物種: Borreliella burgdorferi (Lyme disease spirochete)
• 細胞内の位置: Cell outer membrane ; Lipid-anchor : O06878
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 141097.06

構造登録者

Eicken, C.,Sharma, V.,Klabunde, T.,Lawrenz, M.B.,Hardham, J.M.,Norris, S.J.,Sacchettini, J.C. (登録日: 2002-03-21, 公開日: 2002-06-19, 最終更新日: 2024-11-20)

主引用文献

Eicken, C.,Sharma, V.,Klabunde, T.,Lawrenz, M.B.,Hardham, J.M.,Norris, S.J.,Sacchettini, J.C.
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.
J.Biol.Chem., 277:21691-21696, 2002

PubMed Abstract: VlsE is an outer surface lipoprotein of Borrelia burgdorferi that undergoes antigenic variation through an elaborate gene conversion mechanism and is thought to play a major role in the immune response to the Lyme disease borellia. The crystal structure of recombinant variant protein VlsE1 at 2.3-A resolution reveals that the six variable regions form loop structures that constitute most of the membrane distal surface of VlsE, covering the predominantly alpha-helical, invariant regions of the protein. The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion.

PubMed: 11923306
DOI: 10.1074/jbc.M201547200

実験手法

X-RAY DIFFRACTION (2.3 Å)