1L7G

Crystal structure of E119G mutant influenza virus neuraminidase in complex with BCX-1812

1L7G の概要

• エントリーDOI: 10.2210/pdb1l7g/pdb
• 関連するPDBエントリー: 1L7F 1L7H
• 分子名称: neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: neuraminidase, hydrolase, influenza, glycosylated protein, bcx-1812, e119g mutant
• 由来する生物種: Influenza A virus
• 細胞内の位置: Virion membrane (By similarity): P03472
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46217.27

構造登録者

Smith, B.J.,McKimm-Breshkin, J.L.,McDonald, M.,Fernley, R.T.,Varghese, J.N.,Colman, P.M. (登録日: 2002-03-15, 公開日: 2002-05-29, 最終更新日: 2021-10-27)

• 主引用文献: Smith, B.J.,McKimm-Breshkin, J.L.,McDonald, M.,Fernley, R.T.,Varghese, J.N.,Colman, P.M.; Structural studies of the resistance of influenza virus neuramindase to inhibitors.; J.Med.Chem., 45:2207-2212, 2002; PubMed: 12014958; DOI: 10.1021/jm010528u

実験手法

X-RAY DIFFRACTION (1.85 Å)