1L7F

Crystal structure of influenza virus neuraminidase in complex with BCX-1812

Summary for 1L7F

• Entry DOI: 10.2210/pdb1l7f/pdb
• Related: 1L7G 1L7H 1NNC 2QWK
• Descriptor: neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: n9 neuraminidase, hydrolase, influenza, glycosylated protein, bcx-1812
• Biological source: Influenza A virus
• Cellular location: Virion membrane (By similarity): P03472
• Total number of polymer chains: 1
• Total formula weight: 46289.33

Authors

Smith, B.J.,McKimm-Breshkin, J.L.,McDonald, M.,Fernley, R.T.,Varghese, J.N.,Colman, P.M. (deposition date: 2002-03-15, release date: 2002-05-29, Last modification date: 2020-07-29)

• Primary citation: Smith, B.J.,McKimm-Breshkin, J.L.,McDonald, M.,Fernley, R.T.,Varghese, J.N.,Colman, P.M.; Structural studies of the resistance of influenza virus neuramindase to inhibitors.; J.Med.Chem., 45:2207-2212, 2002; PubMed: 12014958; DOI: 10.1021/jm010528u

Experimental method

X-RAY DIFFRACTION (1.8 Å)