1L1S

Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum

Summary for 1L1S

• Entry DOI: 10.2210/pdb1l1s/pdb
• Descriptor: hypothetical protein MTH1491 (2 entities in total)
• Functional Keywords: structural genomics, hypothetical protein, psi, protein structure initiative, midwest center for structural genomics, mcsg, unknown function
• Biological source: Methanothermobacter thermautotrophicus
• Total number of polymer chains: 1
• Total formula weight: 12753.67

Authors

Christendat, D.,Saridakis, V.,Kim, Y.,Kumar, P.A.,Xu, X.,Semesi, A.,Joachimiak, A.,Arrowsmith, C.H.,Edwards, A.M.,Midwest Center for Structural Genomics (MCSG) (deposition date: 2002-02-19, release date: 2002-05-29, Last modification date: 2024-10-30)

Primary citation

Christendat, D.,Saridakis, V.,Kim, Y.,Kumar, P.A.,Xu, X.,Semesi, A.,Joachimiak, A.,Arrowsmith, C.H.,Edwards, A.M.
The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.
Protein Sci., 11:1409-1414, 2002

PubMed Abstract: As part of our structural proteomics initiative, we have determined the crystal structure of MTH1491, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum. MTH1491 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized proteins. It belongs to a family of proteins whose biological function is not known. The crystal structure of MTH1491, the first structure for this family of proteins, consists of an overall five-stranded parallel beta-sheet with strand order 51234 and flanking helices. The oligomeric form of this molecule is a trimer as seen from both crystal contacts and gel filtration studies. Analysis revealed that the structure of MTH1491 is similar to that of dehydrogenases, amidohydrolases, and oxidoreductases. Using a combination of sequence and structural analyses, we showed that MTH1491 does not belong to either the dehydrogenase or the amidohydrolase superfamilies of proteins.

PubMed: 12021439
DOI: 10.1110/ps.4720102

Experimental method

X-RAY DIFFRACTION (2.3 Å)