1KVH

NCSi-gb-bulge-DNA complex induced formation of a DNA bulge structure by a molecular wedge ligand-post-activated neocarzinostatin chromophore

Summary for 1KVH

• Entry DOI: 10.2210/pdb1kvh/pdb
• Descriptor: 5'-D(*CP*CP*CP*GP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*TP*TP*CP*GP*GP*G)-3', SPIRO[[7-METHOXY-5-METHYL-1,2-DIHYDRO-NAPHTHALENE]-3,1'-[5-HYDROXY-9-[2-METHYLAMINO-2,6-DIDEOXYGALACTOPYRANOSYL-OXY]-5-(2-OXO-[1,3]DIOXOLAN-4-YL)-3A,5,9,9A-TETRAHYDRO-3H-1-OXA-CYCLOPENTA[A]-S-INDACEN-2-ONE]] (3 entities in total)
• Functional Keywords: dna
• Total number of polymer chains: 2
• Total formula weight: 6135.27

Authors

Gao, X.,Stassinopoulos, A.,Ji, J.,Kwon, Y.,Bare, S.,Goldberg, I.H. (deposition date: 2002-01-26, release date: 2002-06-19, Last modification date: 2022-02-23)

• Primary citation: Gao, X.,Stassinopoulos, A.,Ji, J.,Kwon, Y.,Bare, S.,Goldberg, I.H.; Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore.; Biochemistry, 41:5131-5143, 2002; PubMed: 11955061; DOI: 10.1021/bi012112o

Experimental method

SOLUTION NMR