1KVE

KILLER TOXIN FROM HALOTOLERANT YEAST

1KVE の概要

• エントリーDOI: 10.2210/pdb1kve/pdb
• 分子名称: SMK TOXIN (3 entities in total)
• 機能のキーワード: toxin, halotolerant yeast
• 由来する生物種: Pichia farinosa; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 28411.57

構造登録者

Kashiwagi, T.,Kunishima, N.,Suzuki, C.,Tsuchiya, F.,Nikkuni, S.,Arata, Y.,Morikawa, K. (登録日: 1996-10-04, 公開日: 1997-04-01, 最終更新日: 2024-10-16)

主引用文献

Kashiwagi, T.,Kunishima, N.,Suzuki, C.,Tsuchiya, F.,Nikkuni, S.,Arata, Y.,Morikawa, K.
The novel acidophilic structure of the killer toxin from halotolerant yeast demonstrates remarkable folding similarity with a fungal killer toxin.
Structure, 5:81-94, 1997

PubMed Abstract: Several strains of yeasts and fungi produce proteinous substances, termed killer toxins, which kill sensitive strains. The SMK toxin, secreted by the halotolerant yeast Pichia farinosa KK1 strain, uniquely exhibits its maximum killer activity under conditions of acidic pH and high salt concentration. The toxin is composed of two distinct subunits, alpha and beta, which tightly interact with each other under acidic conditions. However, they are easily dissociated under neutral conditions and lose the killer activity. The three-dimensional structure of the SMK toxin will provide a better understanding of the mechanism of toxicity of this protein and the cause of its unique pH-dependent stability.

PubMed: 9016714
DOI: 10.1016/S0969-2126(97)00168-8

実験手法

X-RAY DIFFRACTION (1.8 Å)