1KLK

CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH

Summary for 1KLK

Entry DOI	10.2210/pdb1klk/pdb
Descriptor	Dihydrofolate reductase, [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	structure-based design, antifolate, aids, protein-inhibitor complex, oxidoreductase, nadp, one-carbon metabolism
Biological source	Pneumocystis carinii
Total number of polymer chains	1
Total formula weight	25031.36
Authors	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Queener, S.F. (deposition date: 2001-12-12, release date: 2002-12-12, Last modification date: 2024-02-14)
Primary citation	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Queener, S.F. Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Acta Crystallogr.,Sect.D, 58:946-954, 2002 Cited by PubMed: 12037296 DOI: 10.1107/S090744490200505X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation