1KLK

CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH

1KLK の概要

• エントリーDOI: 10.2210/pdb1klk/pdb
• 分子名称: Dihydrofolate reductase, [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: structure-based design, antifolate, aids, protein-inhibitor complex, oxidoreductase, nadp, one-carbon metabolism
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25031.36

構造登録者

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Queener, S.F. (登録日: 2001-12-12, 公開日: 2002-12-12, 最終更新日: 2024-02-14)

• 主引用文献: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Queener, S.F.; Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.; Acta Crystallogr.,Sect.D, 58:946-954, 2002; PubMed: 12037296; DOI: 10.1107/S090744490200505X

実験手法

X-RAY DIFFRACTION (2.3 Å)