1KIT

VIBRIO CHOLERAE NEURAMINIDASE

Summary for 1KIT

Entry DOI	10.2210/pdb1kit/pdb
Descriptor	SIALIDASE, CALCIUM ION (3 entities in total)
Functional Keywords	hydrolase, glycosidase, calcium
Biological source	Vibrio cholerae
Cellular location	Secreted: P37060
Total number of polymer chains	1
Total formula weight	83119.63
Authors	Taylor, G.L.,Crennell, S.J.,Garman, E.F.,Vimr, E.R.,Laver, W.G. (deposition date: 1996-06-21, release date: 1997-06-05, Last modification date: 2024-02-14)
Primary citation	Crennell, S.,Garman, E.,Laver, G.,Vimr, E.,Taylor, G. Crystal structure of Vibrio cholerae neuraminidase reveals dual lectin-like domains in addition to the catalytic domain. Structure, 2:535-544, 1994 Cited by PubMed Abstract: Vibrio cholerae neuraminidase is part of a mucinase complex which may function in pathogenesis by degrading the mucin layer of the gastrointestinal tract. The neuraminidase, which has been the target of extensive inhibitor studies, plays a subtle role in the pathology of the bacterium, by processing higher order gangliosides to GM1, the receptor for cholera toxin. PubMed: 7922030 DOI: 10.1016/S0969-2126(00)00053-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation