1KIT

VIBRIO CHOLERAE NEURAMINIDASE

1KIT の概要

• エントリーDOI: 10.2210/pdb1kit/pdb
• 分子名称: SIALIDASE, CALCIUM ION (3 entities in total)
• 機能のキーワード: hydrolase, glycosidase, calcium
• 由来する生物種: Vibrio cholerae
• 細胞内の位置: Secreted: P37060
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83119.63

構造登録者

Taylor, G.L.,Crennell, S.J.,Garman, E.F.,Vimr, E.R.,Laver, W.G. (登録日: 1996-06-21, 公開日: 1997-06-05, 最終更新日: 2024-02-14)

主引用文献

Crennell, S.,Garman, E.,Laver, G.,Vimr, E.,Taylor, G.
Crystal structure of Vibrio cholerae neuraminidase reveals dual lectin-like domains in addition to the catalytic domain.
Structure, 2:535-544, 1994

PubMed Abstract: Vibrio cholerae neuraminidase is part of a mucinase complex which may function in pathogenesis by degrading the mucin layer of the gastrointestinal tract. The neuraminidase, which has been the target of extensive inhibitor studies, plays a subtle role in the pathology of the bacterium, by processing higher order gangliosides to GM1, the receptor for cholera toxin.

PubMed: 7922030
DOI: 10.1016/S0969-2126(00)00053-8

実験手法

X-RAY DIFFRACTION (2.3 Å)