1KHX

Crystal structure of a phosphorylated Smad2

Summary for 1KHX

• Entry DOI: 10.2210/pdb1khx/pdb
• Related: 1DEV
• Descriptor: Smad2 (2 entities in total)
• Functional Keywords: tgf-beta signaling, smad2, phosphorylation, receptor kinase signaling, cancer, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q15796
• Total number of polymer chains: 1
• Total formula weight: 25540.67

Authors

Wu, J.-W.,Hu, M.,Chai, J.,Seoane, J.,Huse, M.,Kyin, S.,Muir, T.W.,Fairman, R.,Massague, J.,Shi, Y. (deposition date: 2001-12-01, release date: 2002-02-06, Last modification date: 2011-07-13)

• Primary citation: Wu, J.W.,Hu, M.,Chai, J.,Seoane, J.,Huse, M.,Li, C.,Rigotti, D.J.,Kyin, S.,Muir, T.W.,Fairman, R.,Massague, J.,Shi, Y.; Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.; Mol.Cell, 8:1277-1289, 2001; PubMed: 11779503; DOI: 10.1016/S1097-2765(01)00421-X

Experimental method

X-RAY DIFFRACTION (1.8 Å)