1KGC

Immune Receptor

1KGC の概要

• エントリーDOI: 10.2210/pdb1kgc/pdb
• 分子名称: T-cell receptor alpha chain, T-cell receptor beta chain (3 entities in total)
• 機能のキーワード: t-cell receptor, lc13 clone, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass membrane protein (Potential): P01848 P01850
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50165.59

構造登録者

Kjer-Nielsen, L.,Clements, C.S.,Brooks, A.G.,Purcell, A.W.,McCluskey, J.,Rossjohn, J. (登録日: 2001-11-26, 公開日: 2002-12-11, 最終更新日: 2024-11-13)

主引用文献

Kjer-Nielsen, L.,Clements, C.S.,Brooks, A.G.,Purcell, A.W.,McCluskey, J.,Rossjohn, J.
The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance
STRUCTURE, 10:1521-1532, 2002

PubMed Abstract: Despite a potential repertoire of >10(15) alphabeta T cell receptors (TcR), the HLA B8-restricted cytolytic T cell response to a latent antigen of Epstein-Barr virus (EBV) is strikingly limited in the TcR sequences that are selected. Even in unrelated individuals this response is dominated by a single highly restricted TcR clonotype that selects identical combinations of hypervariable Valpha, Vbeta, D, J, and N region genes. We have determined the 1.5 A crystal structure of this "public" TcR, revealing that five of the six hypervariable loops adopt novel conformations providing a unique combining site that contains a deep pocket predicted to overlay the HLA B8-peptide complex. The findings suggest a structural basis for the immunodominance of this clonotype in the immune response to EBV.

PubMed: 12429093
DOI: 10.1016/S0969-2126(02)00878-X

実験手法

X-RAY DIFFRACTION (1.5 Å)