1KEN

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION

Summary for 1KEN

• Entry DOI: 10.2210/pdb1ken/pdb
• Descriptor: hemagglutinin HA1, hemagglutinin HA2, influenza virus infectivity neutralizing antibody (light chain), ... (5 entities in total)
• Functional Keywords: hemagglutinin, envelope protein, glycoprotein, viral protein-immune system complex, viral protein/immune system
• Biological source: Influenza A virus (A/X-31(H3N2)); More
• Cellular location: Virion membrane; Single-pass type I membrane protein (Potential): P03437
• Total number of polymer chains: 10
• Total formula weight: 265848.68

Authors

Barbey-Martin, C.,Gigant, B.,Bizebard, T.,Calder, L.J.,Wharto, S.A.,Skehel, J.J.,Knossow, M. (deposition date: 2001-11-16, release date: 2002-04-24, Last modification date: 2024-10-09)

Primary citation

Barbey-Martin, C.,Gigant, B.,Bizebard, T.,Calder, L.J.,Wharton, S.A.,Skehel, J.J.,Knossow, M.
An Antibody that Prevents the Hemagglutinin Low pH Fusogenic Transition
VIROLOGY, 294:70-74, 2002

PubMed Abstract: We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

PubMed: 11886266
DOI: 10.1006/viro.2001.1320

Experimental method

X-RAY DIFFRACTION (3.5 Å)