1KE8

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE

Summary for 1KE8

Related1KE5 1KE6 1KE7 1KE9
DescriptorCELL DIVISION PROTEIN KINASE 2, 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE (3 entities in total)
Functional Keywordscyclin kinase, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34374.95
Authors
Bramson, H.N.,Corona, J.,Davis, S.T.,Dickerson, S.H.,Edelstein, M.,Frye, S.V.,Gampe, R.T.,Hassell, A.M.,Shewchuk, L.M.,Kuyper, L.F. (deposition date: 2001-11-14, release date: 2002-05-14, Last modification date: 2018-01-31)
Primary citation
Bramson, H.N.,Corona, J.,Davis, S.T.,Dickerson, S.H.,Edelstein, M.,Frye, S.V.,Gampe Jr., R.T.,Harris, P.A.,Hassell, A.,Holmes, W.D.,Hunter, R.N.,Lackey, K.E.,Lovejoy, B.,Luzzio, M.J.,Montana, V.,Rocque, W.J.,Rusnak, D.,Shewchuk, L.,Veal, J.M.,Walker, D.H.,Kuyper, L.F.
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
J.Med.Chem., 44:4339-4358, 2001
PubMed: 11728181 (PDB entries with the same primary citation)
DOI: 10.1021/jm010117d
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers90.7%0.8%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report