1KE5

CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide

1KE5 の概要

関連するPDBエントリー1KE6 1KE7 1KE8 1KE9
分子名称Cell division protein kinase 2, N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE (3 entities in total)
機能のキーワードcyclin kinase, transferase
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
ポリマー鎖数1
分子量合計34305.86
構造登録者
Bramson, H.N.,Corona, J.,Davis, S.T.,Dickerson, S.H.,Edelstein, M.,Frye, S.V.,Gampe, R.T.,Hassell, A.M.,Shewchuk, L.M.,Kuyper, L.F. (登録日: 2001-11-14, 公開日: 2002-05-14, 最終更新日: 2018-01-31)
主引用文献
Bramson, H.N.,Corona, J.,Davis, S.T.,Dickerson, S.H.,Edelstein, M.,Frye, S.V.,Gampe Jr., R.T.,Harris, P.A.,Hassell, A.,Holmes, W.D.,Hunter, R.N.,Lackey, K.E.,Lovejoy, B.,Luzzio, M.J.,Montana, V.,Rocque, W.J.,Rusnak, D.,Shewchuk, L.,Veal, J.M.,Walker, D.H.,Kuyper, L.F.
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
J.Med.Chem., 44:4339-4358, 2001
PubMed: 11728181 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm010117d
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers140.4%03.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード