1K8I

CRYSTAL STRUCTURE OF MOUSE H2-DM

Summary for 1K8I

• Entry DOI: 10.2210/pdb1k8i/pdb
• Descriptor: MHC class II H2-M alpha chain, MHC class II H2-M beta 2 chain, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: mhc, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 43239.24

Authors

Fremont, D.H.,Crawford, F.,Marrack, P.,Hendrickson, W.,Kappler, J. (deposition date: 2001-10-24, release date: 2001-12-05, Last modification date: 2024-11-13)

Primary citation

Fremont, D.H.,Crawford, F.,Marrack, P.,Hendrickson, W.A.,Kappler, J.
Crystal structure of mouse H2-M.
Immunity, 9:385-393, 1998

PubMed Abstract: H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor.

PubMed: 9768758
DOI: 10.1016/S1074-7613(00)80621-4

Experimental method

X-RAY DIFFRACTION (3.1 Å)