1K2P

Crystal structure of Bruton's tyrosine kinase domain

1K2P の概要

• エントリーDOI: 10.2210/pdb1k2p/pdb
• 分子名称: Tyrosine-protein kinase BTK (1 entity in total)
• 機能のキーワード: bruton tryosine kinase, kinase domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q06187
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61496.80

構造登録者

Mao, C.,Zhou, M.,Uckun, F.M. (登録日: 2001-09-28, 公開日: 2002-06-26, 最終更新日: 2024-02-07)

主引用文献

Mao, C.,Zhou, M.,Uckun, F.M.
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
J.Biol.Chem., 276:41435-41443, 2001

PubMed Abstract: Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided.

PubMed: 11527964
DOI: 10.1074/jbc.M104828200

実験手法

X-RAY DIFFRACTION (2.1 Å)