1K1V

Solution Structure of the DNA-Binding Domain of MafG

1K1V の概要

• エントリーDOI: 10.2210/pdb1k1v/pdb
• 分子名称: MafG (1 entity in total)
• 機能のキーワード: maf, transcription factor, dna-binding domain, dna binding protein
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Nucleus (By similarity): O54790
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4962.73

構造登録者

Kusunoki, H.,Motohashi, H.,Katsuoka, F.,Morohashi, A.,Yamamoto, M.,Tanaka, T. (登録日: 2001-09-25, 公開日: 2002-04-10, 最終更新日: 2024-05-29)

主引用文献

Kusunoki, H.,Motohashi, H.,Katsuoka, F.,Morohashi, A.,Yamamoto, M.,Tanaka, T.
Solution structure of the DNA-binding domain of MafG.
Nat.Struct.Biol., 9:252-256, 2002

PubMed Abstract: The Maf family proteins, which constitute a subgroup of basic region-leucine zipper (bZIP) proteins, function as transcriptional regulators of cellular differentiation. Together with the basic region, the Maf extended homology region (EHR), conserved only within the Maf family, defines the DNA binding specific to Mafs. Here we present the first NMR-derived structure of the DNA-binding domain (residues 1-76) of MafG, which contains the EHR and the basic region. The structure consists of three alpha-helices and resembles the fold of the DNA-binding domain of Skn-1, a developmental transcription factor of Caenorhabditis elegans. The structural similarity between MafG and Skn-1 enables us to propose a possible mechanism by which Maf family proteins recognize their consensus DNA sequences.

PubMed: 11875518
DOI: 10.1038/nsb771

実験手法

SOLUTION NMR