1K1F

Structure of the Bcr-Abl Oncoprotein Oligomerization domain

1K1F の概要

• エントリーDOI: 10.2210/pdb1k1f/pdb
• 分子名称: BREAKPOINT CLUSTER REGION PROTEIN (2 entities in total)
• 機能のキーワード: oligomerization, coiled coil, bcr-abl kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 69675.50

構造登録者

Zhao, X.,Ghaffari, S.,Lodish, H.,Malashkevich, V.N.,Kim, P.S. (登録日: 2001-09-25, 公開日: 2002-02-06, 最終更新日: 2024-10-30)

主引用文献

Zhao, X.,Ghaffari, S.,Lodish, H.,Malashkevich, V.N.,Kim, P.S.
Structure of the Bcr-Abl oncoprotein oligomerization domain.
Nat.Struct.Biol., 9:117-120, 2002

PubMed Abstract: The Bcr-Abl oncoprotein is responsible for a wide range of human leukemias, including most cases of Philadelphia chromosome-positive chronic myelogenous leukemia. Oligomerization of Bcr-Abl is essential for oncogenicity. We determined the crystal structure of the N-terminal oligomerization domain of Bcr-Abl (residues 1-72 or Bcr1-72) and found a novel mode of oligomer formation. Two N-shaped monomers dimerize by swapping N-terminal helices and by forming an antiparallel coiled coil between C-terminal helices. Two dimers then stack onto each other to form a tetramer. The Bcr1-72 structure provides a basis for the design of inhibitors of Bcr-Abl transforming activity by disrupting Bcr-Abl oligomerization.

PubMed: 11780146

実験手法

X-RAY DIFFRACTION (2.2 Å)