1JXO

Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95

1JXO の概要

• エントリーDOI: 10.2210/pdb1jxo/pdb
• 関連するPDBエントリー: 1JXM
• 分子名称: postsynaptic density protein (2 entities in total)
• 機能のキーワード: maguk, postsynaptic density, sh3 domain, guanylate kinase domain, structural protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cell membrane; Peripheral membrane protein: P31016
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69625.99

構造登録者

Tavares, G.A.,Panepucci, E.H.,Brunger, A.T. (登録日: 2001-09-07, 公開日: 2002-01-16, 最終更新日: 2023-08-16)

主引用文献

Tavares, G.A.,Panepucci, E.H.,Brunger, A.T.
Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.
Mol.Cell, 8:1313-1325, 2001

PubMed Abstract: PSD-95/SAP90 is a member of the MAGUK superfamily. In excitatory synapses, PSD-95 clusters receptors and ion channels at specific sites in the postsynaptic membrane and organizes downstream signaling and cytoskeletal molecules. We have determined the crystal structures of the apo and GMP-bound forms to 2.3 and 2.0 A resolutions, respectively, of a fragment containing the SH3, HOOK, and guanylate kinase (GK) domains of PSD-95. We observe an intramolecular interaction between the SH3 and GK domains involving the formation of a beta sheet including residues N- and C-terminal to the GK domain. Based on amino acid conservation and mutational data available in the literature, we propose that this intramolecular interaction is a common feature among MAGUK proteins.

PubMed: 11779506
DOI: 10.1016/S1097-2765(01)00416-6

実験手法

X-RAY DIFFRACTION (2.3 Å)