1JVQ

Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive loop peptide, and an exogenous tetrapeptide

Summary for 1JVQ

• Entry DOI: 10.2210/pdb1jvq/pdb
• Related: 1BR8
• Descriptor: ANTITHROMBIN-III, P14-P8 reactive loop peptide, exogenous Cholecystokinin tetrapeptide, ... (6 entities in total)
• Functional Keywords: loop-sheet polymer, beta-barrel, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P01008
• Total number of polymer chains: 4
• Total formula weight: 101450.25

Authors

Zhou, A.,Huntington, J.A.,Lomas, D.A.,Carrell, R.W.,Stein, P.E. (deposition date: 2001-08-31, release date: 2003-06-03, Last modification date: 2023-08-16)

• Primary citation: Zhou, A.,Stein, P.E.,Huntington, J.A.,Sivasothy, P.,Lomas, D.A.,Carrell, R.W.; How small peptides block and reverse serpin polymerisation; J.Mol.Biol., 342:931-941, 2004; PubMed: 15342247; DOI: 10.1016/j.jmb.2004.07.078

Experimental method

X-RAY DIFFRACTION (2.6 Å)