1JSV

The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide

Summary for 1JSV

DescriptorCELL DIVISION PROTEIN KINASE 2, 4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE (3 entities in total)
Functional Keywordscdk2, serine/threonine protein kinase, cell cycle, atp-binding, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34241.78
Authors
Watenpaugh, K.D.,Kelley, L.C. (deposition date: 2001-08-19, release date: 2001-08-29, Last modification date: 2018-04-04)
Primary citation
Clare, P.M.,Poorman, R.A.,Kelley, L.C.,Watenpaugh, K.D.,Bannow, C.A.,Leach, K.L.
The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism
J.Biol.Chem., 276:48292-48299, 2001
PubMed: 11604388 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.96 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers2209.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload