1JSV
The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide
Summary for 1JSV
Entry DOI | 10.2210/pdb1jsv/pdb |
Descriptor | CELL DIVISION PROTEIN KINASE 2, 4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE (3 entities in total) |
Functional Keywords | cdk2, serine/threonine protein kinase, cell cycle, atp-binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34241.78 |
Authors | Watenpaugh, K.D.,Kelley, L.C. (deposition date: 2001-08-19, release date: 2001-08-29, Last modification date: 2024-02-07) |
Primary citation | Clare, P.M.,Poorman, R.A.,Kelley, L.C.,Watenpaugh, K.D.,Bannow, C.A.,Leach, K.L. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism J.Biol.Chem., 276:48292-48299, 2001 Cited by PubMed: 11604388PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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