1JSD

CRYSTAL STRUCTURE OF SWINE H9 HAEMAGGLUTININ

1JSD の概要

• エントリーDOI: 10.2210/pdb1jsd/pdb
• 関連するPDBエントリー: 1JSH 1JSI 1JSM 1JSN 1JSO
• 分子名称: HAEMAGGLUTININ (HA1 CHAIN), HAEMAGGLUTININ (HA2 CHAIN), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: influenza, viral protein
• 由来する生物種: Influenza A virus (A/swine/Hong Kong/9/98(H9N2)); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57509.02

構造登録者

Ha, Y.,Steven, D.J.,Skehel, J.J.,Wiley, D.C. (登録日: 2001-08-17, 公開日: 2001-09-26, 最終更新日: 2024-10-30)

主引用文献

Ha, Y.,Stevens, D.J.,Skehel, J.J.,Wiley, D.C.
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes.
EMBO J., 21:865-875, 2002

PubMed Abstract: There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.

PubMed: 11867515
DOI: 10.1093/emboj/21.5.865

実験手法

X-RAY DIFFRACTION (1.8 Å)