1JQH

IGF-1 receptor kinase domain

Summary for 1JQH

• Entry DOI: 10.2210/pdb1jqh/pdb
• Related: 1IR3 1IRK
• Descriptor: IGF-1 receptor kinase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: protein kinase fold, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P08069
• Total number of polymer chains: 3
• Total formula weight: 107137.70

Authors

Pautsch, A.,Zoephel, A.,Ahorn, H.,Spevak, W.,Hauptmann, R.,Nar, H. (deposition date: 2001-08-07, release date: 2002-04-19, Last modification date: 2024-12-25)

Primary citation

Pautsch, A.,Zoephel, A.,Ahorn, H.,Spevak, W.,Hauptmann, R.,Nar, H.
Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Structure, 9:955-965, 2001

PubMed Abstract: The insulin-like growth-factor-1 (IGF-1) receptor, which is widely expressed in cells that have undergone oncogenic transformation, is emerging as a novel target in cancer therapy. IGF-1-induced receptor activation results in autophosphorylation of cytoplasmic kinase domains and enhances their capability to phosphorylate downstream substrates. Structures of the homologous insulin receptor kinase (IRK) exist in an open, unphosphorylated form and a closed, trisphosphorylated form.

PubMed: 11591350
DOI: 10.1016/S0969-2126(01)00655-4

Experimental method

X-RAY DIFFRACTION (2.1 Å)