1JQH

IGF-1 receptor kinase domain

1JQH の概要

• エントリーDOI: 10.2210/pdb1jqh/pdb
• 関連するPDBエントリー: 1IR3 1IRK
• 分子名称: IGF-1 receptor kinase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protein kinase fold, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08069
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 107137.70

構造登録者

Pautsch, A.,Zoephel, A.,Ahorn, H.,Spevak, W.,Hauptmann, R.,Nar, H. (登録日: 2001-08-07, 公開日: 2002-04-19, 最終更新日: 2024-12-25)

主引用文献

Pautsch, A.,Zoephel, A.,Ahorn, H.,Spevak, W.,Hauptmann, R.,Nar, H.
Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Structure, 9:955-965, 2001

PubMed Abstract: The insulin-like growth-factor-1 (IGF-1) receptor, which is widely expressed in cells that have undergone oncogenic transformation, is emerging as a novel target in cancer therapy. IGF-1-induced receptor activation results in autophosphorylation of cytoplasmic kinase domains and enhances their capability to phosphorylate downstream substrates. Structures of the homologous insulin receptor kinase (IRK) exist in an open, unphosphorylated form and a closed, trisphosphorylated form.

PubMed: 11591350
DOI: 10.1016/S0969-2126(01)00655-4

実験手法

X-RAY DIFFRACTION (2.1 Å)