1JQA

Bacillus stearothermophilus glycerol dehydrogenase complex with glycerol

Summary for 1JQA

• Entry DOI: 10.2210/pdb1jqa/pdb
• Related: 1JPU 1JQ5
• Descriptor: Glycerol Dehydrogenase, ZINC ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: oxidoreductase, nad, glycerol metabolism
• Biological source: Geobacillus stearothermophilus
• Total number of polymer chains: 1
• Total formula weight: 39787.91

Authors

Ruzheinikov, S.N.,Burke, J.,Sedelnikova, S.,Baker, P.J.,Taylor, R.,Bullough, P.A.,Muir, N.M.,Gore, M.G.,Rice, D.W. (deposition date: 2001-08-04, release date: 2001-10-03, Last modification date: 2023-08-16)

Primary citation

Ruzheinikov, S.N.,Burke, J.,Sedelnikova, S.,Baker, P.J.,Taylor, R.,Bullough, P.A.,Muir, N.M.,Gore, M.G.,Rice, D.W.
Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
Structure, 9:789-802, 2001

PubMed Abstract: Bacillus stearothermophilus glycerol dehydrogenase (GlyDH) (glycerol:NAD(+) 2-oxidoreductase, EC 1.1.1.6) catalyzes the oxidation of glycerol to dihydroxyacetone (1,3-dihydroxypropanone) with concomitant reduction of NAD(+) to NADH. Analysis of the sequence of this enzyme indicates that it is a member of the so-called iron-containing alcohol dehydrogenase family. Despite this sequence similarity, GlyDH shows a strict dependence on zinc for activity. On the basis of this, we propose to rename this group the family III metal-dependent polyol dehydrogenases. To date, no structural data have been reported for any enzyme in this group.

PubMed: 11566129
DOI: 10.1016/S0969-2126(01)00645-1

Experimental method

X-RAY DIFFRACTION (2.05 Å)