1JQA

Bacillus stearothermophilus glycerol dehydrogenase complex with glycerol

1JQA の概要

• エントリーDOI: 10.2210/pdb1jqa/pdb
• 関連するPDBエントリー: 1JPU 1JQ5
• 分子名称: Glycerol Dehydrogenase, ZINC ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, nad, glycerol metabolism
• 由来する生物種: Geobacillus stearothermophilus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39787.91

構造登録者

Ruzheinikov, S.N.,Burke, J.,Sedelnikova, S.,Baker, P.J.,Taylor, R.,Bullough, P.A.,Muir, N.M.,Gore, M.G.,Rice, D.W. (登録日: 2001-08-04, 公開日: 2001-10-03, 最終更新日: 2023-08-16)

主引用文献

Ruzheinikov, S.N.,Burke, J.,Sedelnikova, S.,Baker, P.J.,Taylor, R.,Bullough, P.A.,Muir, N.M.,Gore, M.G.,Rice, D.W.
Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
Structure, 9:789-802, 2001

PubMed Abstract: Bacillus stearothermophilus glycerol dehydrogenase (GlyDH) (glycerol:NAD(+) 2-oxidoreductase, EC 1.1.1.6) catalyzes the oxidation of glycerol to dihydroxyacetone (1,3-dihydroxypropanone) with concomitant reduction of NAD(+) to NADH. Analysis of the sequence of this enzyme indicates that it is a member of the so-called iron-containing alcohol dehydrogenase family. Despite this sequence similarity, GlyDH shows a strict dependence on zinc for activity. On the basis of this, we propose to rename this group the family III metal-dependent polyol dehydrogenases. To date, no structural data have been reported for any enzyme in this group.

PubMed: 11566129
DOI: 10.1016/S0969-2126(01)00645-1

実験手法

X-RAY DIFFRACTION (2.05 Å)