1JO1

N7-Guanine Adduct of 2,7-diaminomitosene with DNA

Summary for 1JO1

• Entry DOI: 10.2210/pdb1jo1/pdb
• Descriptor: 5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3', DECARBAMOYL-2,7-DIAMINOMITOSENE (2 entities in total)
• Functional Keywords: double helix, major groove binding drug, guanine-n7-alkylator, dna
• Total number of polymer chains: 2
• Total formula weight: 7817.38

Authors

Subramaniam, G.,Paz, M.M.,Kumar, G.S.,Das, A.,Palom, Y.,Clement, C.C.,Patel, D.J.,Tomasz, M. (deposition date: 2001-07-26, release date: 2001-09-12, Last modification date: 2022-02-23)

• Primary citation: Subramaniam, G.,Paz, M.M.,Suresh Kumar, G.,Das, A.,Palom, Y.,Clement, C.C.,Patel, D.J.,Tomasz, M.; Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.; Biochemistry, 40:10473-10484, 2001; PubMed: 11523988; DOI: 10.1021/bi010965a

Experimental method

SOLUTION NMR