1JMV

Structure of Haemophylus influenzae Universal Stress Protein At 1.85A Resolution

Summary for 1JMV

• Entry DOI: 10.2210/pdb1jmv/pdb
• Descriptor: Universal Stress Protein A, SULFATE ION (3 entities in total)
• Functional Keywords: universal stress protein, uspa, chaperone
• Biological source: Haemophilus influenzae
• Cellular location: Cytoplasm (By similarity): P44880
• Total number of polymer chains: 4
• Total formula weight: 63488.38

Authors

Sousa, M.C.,McKay, D.B. (deposition date: 2001-07-20, release date: 2001-12-12, Last modification date: 2024-02-07)

Primary citation

Sousa, M.C.,McKay, D.B.
Structure of the universal stress protein of Haemophilus influenzae.
Structure, 9:1135-1141, 2001

PubMed Abstract: The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. However, neither the structure of UspA nor the biochemical mechanism by which it protects cells from the broad spectrum of stress agents is known.

PubMed: 11738040
DOI: 10.1016/S0969-2126(01)00680-3

Experimental method

X-RAY DIFFRACTION (1.85 Å)