1JLM

I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND

1JLM の概要

• エントリーDOI: 10.2210/pdb1jlm/pdb
• 分子名称: INTEGRIN, MANGANESE (II) ION (3 entities in total)
• 機能のキーワード: integrin, cell adhesion protein, glycoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P11215
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22049.05

構造登録者

Lee, J.-O.,Liddington, R. (登録日: 1996-04-09, 公開日: 1997-01-11, 最終更新日: 2024-05-22)

主引用文献

Lee, J.O.,Bankston, L.A.,Arnaout, M.A.,Liddington, R.C.
Two conformations of the integrin A-domain (I-domain): a pathway for activation?
Structure, 3:1333-1340, 1995

PubMed Abstract: Integrins are plasma membrane proteins that mediate adhesion to other cells and to components of the extracellular matrix. Most integrins are constitutively inactive in resting cells, but are rapidly and reversibly activated in response to agonists, leading to highly regulated cell adhesion. This activation is associated with conformational changes in their extracellular portions, but the nature of the structural changes that lead to a change in adhesiveness is not understood. The interactions of several integrins with their extracellular ligands are mediated by an A-type domain (generally called the I-domain in integrins). Binding of the I-domain to protein ligands is dependent on divalent cations. We have described previously the structure of the I-domain from complement receptor 3 with bound Mg2+, in which the glutamate side chain from a second I-domain completes the octahedral coordination sphere of the metal, acting as a ligand mimetic.

PubMed: 8747460
DOI: 10.1016/S0969-2126(01)00271-4

実験手法

X-RAY DIFFRACTION (2 Å)