1JLD

Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere

Summary for 1JLD

Entry DOI	10.2210/pdb1jld/pdb
Related PRD ID	PRD_000341
Descriptor	Pol polyprotein, (2S)-2-tert-butyl-N~4~-(1-ethylpropyl)-N~1~-[(2R,3S)-2-hydroxy-4-phenyl-3-{[N-(quinolin-2-ylcarbonyl)-L-threonyl]amino}butyl]butanediamide (3 entities in total)
Functional Keywords	polyprotein, hiv-2 protease, hydrolase-hydrolase inhibitor complex, aids, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 2
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): Q7SKJ2
Total number of polymer chains	2
Total formula weight	22118.50
Authors	Tong, L. (deposition date: 1997-05-31, release date: 1997-12-03, Last modification date: 2024-02-07)
Primary citation	Beaulieu, P.L.,Wernic, D.,Abraham, A.,Anderson, P.C.,Bogri, T.,Bousquet, Y.,Croteau, G.,Guse, I.,Lamarre, D.,Liard, F.,Paris, W.,Thibeault, D.,Pav, S.,Tong, L. Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere. J.Med.Chem., 40:2164-2176, 1997 Cited by PubMed: 9216835 DOI: 10.1021/jm9606608 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation