1JLD

Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere

1JLD の概要

• エントリーDOI: 10.2210/pdb1jld/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000341
• 分子名称: Pol polyprotein, (2S)-2-tert-butyl-N~4~-(1-ethylpropyl)-N~1~-[(2R,3S)-2-hydroxy-4-phenyl-3-{[N-(quinolin-2-ylcarbonyl)-L-threonyl]amino}butyl]butanediamide (3 entities in total)
• 機能のキーワード: polyprotein, hiv-2 protease, hydrolase-hydrolase inhibitor complex, aids, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 2
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): Q7SKJ2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22118.50

構造登録者

Tong, L. (登録日: 1997-05-31, 公開日: 1997-12-03, 最終更新日: 2024-02-07)

• 主引用文献: Beaulieu, P.L.,Wernic, D.,Abraham, A.,Anderson, P.C.,Bogri, T.,Bousquet, Y.,Croteau, G.,Guse, I.,Lamarre, D.,Liard, F.,Paris, W.,Thibeault, D.,Pav, S.,Tong, L.; Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.; J.Med.Chem., 40:2164-2176, 1997; PubMed: 9216835; DOI: 10.1021/jm9606608

実験手法

X-RAY DIFFRACTION (2.5 Å)