1JKW

STRUCTURE OF CYCLIN MCS2

1JKW の概要

• エントリーDOI: 10.2210/pdb1jkw/pdb
• 分子名称: CYCLIN H (2 entities in total)
• 機能のキーワード: cyclin, cell cycle, cell division, nuclear protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P51946
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37681.44

構造登録者

Andersen, G.,Poterszman, A.,Moras, D.,Thierry, J.C. (登録日: 1996-10-11, 公開日: 1997-01-11, 最終更新日: 2026-01-28)

主引用文献

Andersen, G.,Poterszman, A.,Egly, J.M.,Moras, D.,Thierry, J.C.
The crystal structure of human cyclin H.
FEBS Lett., 397:65-69, 1996

PubMed Abstract: The crystal structure of human cyclin H has been solved at 2.6 A resolution by the MIR method and refined to an R-factor of 23.1%. The core of the molecule consists of two helical repeats adopting the canonical cyclin fold already observed in the structures of cyclin A [Brown et al. (1995) Structure 3, 1235-1247; Jeffrey et al. (1995) Nature 376, 313-320; Russo et al. (1996) Nature 382, 325-331] and TFIIB [Nikoilov et al. (1995) Nature 377, 119-128]. The N-terminal and C-terminal residues form a new domain built on two long helices interacting essentially with the first repeat of the molecule.

PubMed: 8941715
DOI: 10.1016/S0014-5793(96)01143-X

実験手法

X-RAY DIFFRACTION (2.6 Å)