1JJO

Crystal Structure of Mouse Neuroserpin (Cleaved form)

Summary for 1JJO

• Entry DOI: 10.2210/pdb1jjo/pdb
• Descriptor: NEUROSERPIN (3 entities in total)
• Functional Keywords: serpin, serine protease inhibitor, neuronal serpin, signaling protein
• Biological source: Mus musculus (house mouse); More
• Cellular location: Secreted: O35684 O35684 O35684
• Total number of polymer chains: 6
• Total formula weight: 76032.39

Authors

Briand, C.,Kozlov, S.V.,Sonderegger, P.,Gruetter, M.G. (deposition date: 2001-07-09, release date: 2002-01-09, Last modification date: 2024-04-03)

Primary citation

Briand, C.,Kozlov, S.V.,Sonderegger, P.,Grutter, M.G.
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease.
FEBS Lett., 505:18-22, 2001

PubMed Abstract: The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.

PubMed: 11557034
DOI: 10.1016/S0014-5793(01)02764-8

Experimental method

X-RAY DIFFRACTION (3.06 Å)