1JJO

Crystal Structure of Mouse Neuroserpin (Cleaved form)

1JJO の概要

• エントリーDOI: 10.2210/pdb1jjo/pdb
• 分子名称: NEUROSERPIN (3 entities in total)
• 機能のキーワード: serpin, serine protease inhibitor, neuronal serpin, signaling protein
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Secreted: O35684 O35684 O35684
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 76032.39

構造登録者

Briand, C.,Kozlov, S.V.,Sonderegger, P.,Gruetter, M.G. (登録日: 2001-07-09, 公開日: 2002-01-09, 最終更新日: 2024-04-03)

主引用文献

Briand, C.,Kozlov, S.V.,Sonderegger, P.,Grutter, M.G.
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease.
FEBS Lett., 505:18-22, 2001

PubMed Abstract: The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.

PubMed: 11557034
DOI: 10.1016/S0014-5793(01)02764-8

実験手法

X-RAY DIFFRACTION (3.06 Å)