1JI5

Dlp-1 from bacillus anthracis

1JI5 の概要

• エントリーDOI: 10.2210/pdb1ji5/pdb
• 関連するPDBエントリー: 1JI4 1QGH
• 分子名称: Dlp-1, FE (III) ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• 機能のキーワード: dodecamer, four-helix bundle, metal transport
• 由来する生物種: Bacillus anthracis
• 細胞内の位置: Cytoplasm (By similarity): Q8RPQ2
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66044.66

構造登録者

Papinutto, E.,Dundon, W.G.,Pitulis, N.,Battistutta, R.,Montecucco, C.,Zanotti, G. (登録日: 2001-06-29, 公開日: 2002-06-19, 最終更新日: 2024-04-03)

主引用文献

Papinutto, E.,Dundon, W.G.,Pitulis, N.,Battistutta, R.,Montecucco, C.,Zanotti, G.
Structure of two iron-binding proteins from Bacillus anthracis.
J.Biol.Chem., 277:15093-15098, 2002

PubMed Abstract: Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth.

PubMed: 11836250
DOI: 10.1074/jbc.M112378200

実験手法

X-RAY DIFFRACTION (2.5 Å)