1JGS

Multiple Antibiotic Resistance Repressor, MarR

1JGS の概要

• エントリーDOI: 10.2210/pdb1jgs/pdb
• 分子名称: MULTIPLE ANTIBIOTIC RESISTANCE PROTEIN MARR, 2-HYDROXYBENZOIC ACID (2 entities in total)
• 機能のキーワード: transcription regulation, dna-binding, repressor, antibiotic resistance, transcription
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15712.54

構造登録者

Alekshun, M.N.,Levy, S.B.,Mealy, T.R.,Seaton, B.A.,Head, J.F. (登録日: 2001-06-26, 公開日: 2001-12-28, 最終更新日: 2024-02-07)

主引用文献

Alekshun, M.N.,Levy, S.B.,Mealy, T.R.,Seaton, B.A.,Head, J.F.
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution.
Nat.Struct.Biol., 8:710-714, 2001

PubMed Abstract: MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.

PubMed: 11473263
DOI: 10.1038/90429

実験手法

X-RAY DIFFRACTION (2.3 Å)