1JFP
Structure of bovine rhodopsin (dark adapted)
Summary for 1JFP
| Entry DOI | 10.2210/pdb1jfp/pdb |
| Related | 1eds 1edv 1edw 1edx 1fdf |
| Descriptor | rhodopsin, RETINAL (2 entities in total) |
| Functional Keywords | g-protein coupled receptor, signaling protein, membrane protein |
| Biological source | Bos taurus (cattle) |
| Cellular location | Membrane; Multi-pass membrane protein: P02699 |
| Total number of polymer chains | 1 |
| Total formula weight | 39315.89 |
| Authors | Yeagle, P.L.,Choi, G.,Albert, A.D. (deposition date: 2001-06-21, release date: 2001-10-05, Last modification date: 2024-12-25) |
| Primary citation | Yeagle, P.L.,Choi, G.,Albert, A.D. Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms. Biochemistry, 40:11932-11937, 2001 Cited by PubMed Abstract: Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin. PubMed: 11570894DOI: 10.1021/bi015543f PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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