1JES
Crystal Structure of a Copper-Mediated Base Pair in DNA
Summary for 1JES
| Entry DOI | 10.2210/pdb1jes/pdb |
| Related | 1BNA 2ZNA 3ZNA |
| Descriptor | 5'-D(*CP*GP*CP*GP*(DPY)P*AP*TP*(DRP)P*CP*GP*CP*G)-3', COPPER (II) ION (3 entities in total) |
| Functional Keywords | cu, copper, dna, z-dna, dodecamer, duplex, unnatural, designed |
| Total number of polymer chains | 2 |
| Total formula weight | 7423.83 |
| Authors | Atwell, S.,Meggers, E.,Spraggon, G.,Schultz, P.G. (deposition date: 2001-06-18, release date: 2001-11-23, Last modification date: 2024-04-03) |
| Primary citation | Atwell, S.,Meggers, E.,Spraggon, G.,Schultz, P.G. Structure of a Copper-Mediated Base Pair in DNA J.Am.Chem.Soc., 123:12364-12367, 2001 Cited by PubMed Abstract: Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence. PubMed: 11734038DOI: 10.1021/ja011822e PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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