1JC9

TACHYLECTIN 5A FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)

1JC9 の概要

• エントリーDOI: 10.2210/pdb1jc9/pdb
• 関連するPDBエントリー: 1AOC 1TL2
• 分子名称: techylectin-5A, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: lectin, fibrinogen related, sugar binding protein
• 由来する生物種: Tachypleus tridentatus
• 細胞内の位置: Secreted: Q9U8W8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31484.77

構造登録者

Kairies, N.,Beisel, H.-G.,Fuentes-Prior, P.,Tsuda, R.,Muta, T.,Iwanaga, S.,Bode, W.,Huber, R.,Kawabata, S. (登録日: 2001-06-08, 公開日: 2001-11-28, 最終更新日: 2024-10-09)

主引用文献

Kairies, N.,Beisel, H.G.,Fuentes-Prior, P.,Tsuda, R.,Muta, T.,Iwanaga, S.,Bode, W.,Huber, R.,Kawabata, S.
The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.
Proc.Natl.Acad.Sci.USA, 98:13519-13524, 2001

PubMed Abstract: Because invertebrates lack an adaptive immune system, they had to evolve effective intrinsic defense strategies against a variety of microbial pathogens. This ancient form of host defense, the innate immunity, is present in all multicellular organisms including humans. The innate immune system of the Japanese horseshoe crab Tachypleus tridentatus, serving as a model organism, includes a hemolymph coagulation system, which participates both in defense against microbes and in hemostasis. Early work on the evolution of vertebrate fibrinogen suggested a common origin of the arthropod hemolymph coagulation and the vertebrate blood coagulation systems. However, this conjecture could not be verified by comparing the structures of coagulogen, the clotting protein of the horseshoe crab, and of mammalian fibrinogen. Here we report the crystal structure of tachylectin 5A (TL5A), a nonself-recognizing lectin from the hemolymph plasma of T. tridentatus. TL5A shares not only a common fold but also related functional sites with the gamma fragment of mammalian fibrinogen. Our observations provide the first structural evidence of a common ancestor for the innate immunity and the blood coagulation systems.

PubMed: 11707569
DOI: 10.1073/pnas.201523798

実験手法

X-RAY DIFFRACTION (2.01 Å)