1JAQ
COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Summary for 1JAQ
Entry DOI | 10.2210/pdb1jaq/pdb |
Related | 1JAO |
Related PRD ID | PRD_000230 |
Descriptor | MATRIX METALLO PROTEINASE-8 (MET80 FORM), CALCIUM ION, N-[(2R)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alanylglycinamide, ... (5 entities in total) |
Functional Keywords | metalloprotease, zinc-endopeptidase, metzincins, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 1 |
Total formula weight | 18625.04 |
Authors | Grams, F.,Reinemer, P.,Powers, J.C.,Kleine, T.,Piper, M.,Tschesche, H.,Huber, R.,Bode, W. (deposition date: 1996-03-11, release date: 1996-07-11, Last modification date: 2024-02-07) |
Primary citation | Grams, F.,Reinemer, P.,Powers, J.C.,Kleine, T.,Pieper, M.,Tschesche, H.,Huber, R.,Bode, W. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur.J.Biochem., 228:830-841, 1995 Cited by PubMed: 7737183DOI: 10.1111/j.1432-1033.1995.tb20329.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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