1JAO

COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)

Summary for 1JAO

• Entry DOI: 10.2210/pdb1jao/pdb
• Related: 1JAQ
• Related PRD ID: PRD_000232
• Descriptor: MATRIX METALLO PROTEINASE-8 (MET80 FORM), N-[(2S)-2-benzyl-3-sulfanylpropanoyl]-L-alanylglycinamide, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: metalloprotease, zinc-endopeptidase, metzincins, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasmic granule: P22894
• Total number of polymer chains: 1
• Total formula weight: 18646.13

Authors

Grams, F.,Reinemer, P.,Powers, J.C.,Kleine, T.,Piper, M.,Tschesche, H.,Huber, R.,Bode, W. (deposition date: 1996-03-11, release date: 1996-07-11, Last modification date: 2024-02-07)

• Primary citation: Grams, F.,Reinemer, P.,Powers, J.C.,Kleine, T.,Pieper, M.,Tschesche, H.,Huber, R.,Bode, W.; X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.; Eur.J.Biochem., 228:830-841, 1995; PubMed: 7737183; DOI: 10.1111/j.1432-1033.1995.tb20329.x

Experimental method

X-RAY DIFFRACTION (2.4 Å)