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1JAK

Streptomyces plicatus beta-N-acetylhexosaminidase in Complex with (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (IFG)

Summary for 1JAK
Entry DOI10.2210/pdb1jak/pdb
Related1HP4 1HP5
DescriptorBeta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsglycoside hydrolase, family 20, beta-n-acetylhexosaminidase, substrate-assisted catalysis, alpha/beta barrel, isofagomine inhibitor complex, hydrolase
Biological sourceStreptomyces plicatus
Cellular locationMembrane; Multi-pass membrane protein: Q9Y691
Total number of polymer chains1
Total formula weight56809.71
Authors
Mark, B.L.,Vocadlo, D.J.,Zhao, D.,Knapp, S.,Withers, S.G.,James, M.N. (deposition date: 2001-05-30, release date: 2001-11-21, Last modification date: 2023-08-16)
Primary citationMark, B.L.,Vocadlo, D.J.,Zhao, D.,Knapp, S.,Withers, S.G.,James, M.N.
Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
J.Biol.Chem., 276:42131-42137, 2001
Cited by
PubMed: 11522797
DOI: 10.1074/jbc.M107154200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

217705

数据于2024-03-27公开中

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