1JAK

Streptomyces plicatus beta-N-acetylhexosaminidase in Complex with (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (IFG)

1JAK の概要

• エントリーDOI: 10.2210/pdb1jak/pdb
• 関連するPDBエントリー: 1HP4 1HP5
• 分子名称: Beta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: glycoside hydrolase, family 20, beta-n-acetylhexosaminidase, substrate-assisted catalysis, alpha/beta barrel, isofagomine inhibitor complex, hydrolase
• 由来する生物種: Streptomyces plicatus
• 細胞内の位置: Membrane; Multi-pass membrane protein: Q9Y691
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56809.71

構造登録者

Mark, B.L.,Vocadlo, D.J.,Zhao, D.,Knapp, S.,Withers, S.G.,James, M.N. (登録日: 2001-05-30, 公開日: 2001-11-21, 最終更新日: 2023-08-16)

• 主引用文献: Mark, B.L.,Vocadlo, D.J.,Zhao, D.,Knapp, S.,Withers, S.G.,James, M.N.; Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.; J.Biol.Chem., 276:42131-42137, 2001; PubMed: 11522797; DOI: 10.1074/jbc.M107154200

実験手法

X-RAY DIFFRACTION (1.75 Å)