1J9K

CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE

1J9K の概要

• エントリーDOI: 10.2210/pdb1j9k/pdb
• 関連するPDBエントリー: 1J9J 1J9L
• 分子名称: STATIONARY PHASE SURVIVAL PROTEIN, CALCIUM ION, TUNGSTATE(VI)ION, ... (5 entities in total)
• 機能のキーワード: tungstate complex, sure protein, unknown function
• 由来する生物種: Thermotoga maritima
• 細胞内の位置: Cytoplasm (Potential): P96112
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57266.52

構造登録者

Suh, S.W.,Lee, J.Y.,Kwak, J.E.,Moon, J. (登録日: 2001-05-27, 公開日: 2001-09-12, 最終更新日: 2023-10-25)

主引用文献

Lee, J.Y.,Kwak, J.E.,Moon, J.,Eom, S.H.,Liong, E.C.,Pedelacq, J.D.,Berendzen, J.,Suh, S.W.
Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family.
Nat.Struct.Biol., 8:789-794, 2001

PubMed Abstract: Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.

PubMed: 11524683
DOI: 10.1038/nsb0901-789

実験手法

X-RAY DIFFRACTION (2.1 Å)